Resource Type

Journal Article 107

Year

2023 8

2022 17

2021 6

2020 11

2019 2

2018 2

2017 7

2016 3

2015 9

2014 3

2013 4

2012 3

2011 3

2010 6

2009 6

2008 2

2007 3

2006 2

2003 3

2002 1

open ︾

Keywords

carcinoma 3

non-small cell lung cancer 2

numerical simulation 2

1 000 MW nuclear power plant 1

2-dimensional interpolation 1

2′-O-methylation 1

4-nitrophenol 1

ADCP 1

AOD 1

Aerosol pollution levels 1

Aerosol type 1

Antenna 1

Apoptosis 1

Array 1

Artificial intelligence 1

Autophagy 1

BPTF 1

Beclin-1 1

Behavior generation 1

open ︾

Search scope:

排序： Display mode:

Recent advances in small molecule fluorescent probes for simultaneous imaging of two bioactive molecules

Yongqing Zhou, Xin Wang, Wei Zhang, Bo Tang, Ping Li

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1,   Pages 4-33 doi: 10.1007/s11705-021-2041-2

Abstract: The interrelationships and synergistic regulations of bioactive molecules play pivotal roles in physiologicalTherefore, the simultaneous, accurate and timely detection of two bioactive molecules is crucial to exploreFluorescence imaging associated with small molecular probes has been widely used in the imaging of bioactivemolecules in living cells and due to its excellent performances, including high sensitivity and selectivity

Keywords： bioactive molecules     fluorescent probes     in living cells and in vivo     review    

HTML PDF Collect

Chemical transdifferentiation: closer to regenerative medicine

Aining Xu,Lin Cheng

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 152-165 doi: 10.1007/s11684-016-0445-z

Abstract: Small molecules with compelling advantages are a potential alternative in manipulating cell fate conversionretrospect the nature of cell transdifferentiation and summarize the current developments in the research of smallmolecules in promoting cell conversion.

Keywords： cell therapy     cell transdifferentiation     chemical compounds     small molecules     tissue regeneration    

HTML PDF Collect

Emerging immunological strategies: recent advances and future directions

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 805-828 doi: 10.1007/s11684-021-0886-x

Abstract: New approaches that promote anti-tumor immunity have recently been developed, such as small moleculesSmall molecule drugs include agonists and inhibitors that can reach the intracellular or extracellular

Keywords： cancer immunotherapy     bispecific antibodies     small molecules     chimeric antigen receptor T therapy     cancer    

HTML PDF Collect

NADPH oxidase and reactive oxygen species as signaling molecules in carcinogenesis

Gang WANG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 1-7 doi: 10.1007/s11684-009-0018-5

Abstract: Reactive oxygen species (ROS) are small molecule metabolites of oxygen that are prone to participate

Keywords： free radicals     tumor     phox     cell proliferation     cancer therapy    

HTML PDF Collect

Polymorphism of pharmaceutical molecules: perspectives on nucleation

Jie LU, Zhen LI, Xiaolin JIANG,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1,   Pages 37-44 doi: 10.1007/s11705-009-0294-2

Abstract: briefly introduces recent advances in the discovery and control of the polymorphs of pharmaceutical molecules

Keywords： development     Polymorphism     elucidation     controversial     relationship    

HTML PDF Collect

A ruptured recurrent small bowel gastrointestinal stromal tumour causing hemoperitoneum

Eric C.H. Lai,Kam Man Chung,Stephanie H.Y. Lau,Wan Yee Lau

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 108-111 doi: 10.1007/s11684-014-0344-0

Abstract: intra-abdominal recurrence from a previously resected gastrointestinal stromal tumour (GIST) of the smallIn this patient who presented with spontaneous rupture of a small intestinal GIST, the novel use of targeted

Keywords： gastrointestinal stromal tumour     hemoperitoneum     small bowel GIST     small bowel neoplasm     imatinib    

HTML PDF Collect

Simulation and experimental improvement on a small-scale Stirling thermo-acoustic engine

Mao CHEN,Yonglin JU

Frontiers in Energy 2016, Volume 10, Issue 1,   Pages 37-45 doi: 10.1007/s11708-015-0390-6

Abstract: In this paper, the influence of the dimensions of the main parts of the small-scale Stirling thermo-acousticBased on the numerical simulation, a small-scale Stirling thermo-acoustic engine were constructed and

Keywords： thermo-acoustic Stirling engine     small-scale     simulation     experiment    

HTML PDF Collect

Discovery of small molecule degraders for modulating cell cycle

Frontiers of Medicine   Pages 823-854 doi: 10.1007/s11684-023-1027-5

Abstract: The cell cycle is a complex process that involves DNA replication, protein expression, and cell division. Dysregulation of the cell cycle is associated with various diseases. Cyclin-dependent kinases (CDKs) and their corresponding cyclins are major proteins that regulate the cell cycle. In contrast to inhibition, a new approach called proteolysis-targeting chimeras (PROTACs) and molecular glues can eliminate both enzymatic and scaffold functions of CDKs and cyclins, achieving targeted degradation. The field of PROTACs and molecular glues has developed rapidly in recent years. In this article, we aim to summarize the latest developments of CDKs and cyclin protein degraders. The selectivity, application, validation and the current state of each CDK degrader will be overviewed. Additionally, possible methods are discussed for the development of degraders for CDK members that still lack them. Overall, this article provides a comprehensive summary of the latest advancements in CDK and cyclin protein degraders, which will be helpful for researchers working on this topic.

Keywords： PROTAC     molecular glue     degrader     cell cycle     CDK     cyclin    

HTML PDF Collect

Fine-tuning cell organelle dynamics during mitosis by small GTPases

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 339-357 doi: 10.1007/s11684-022-0926-1

Abstract: Small GTPases belonging to the Ras superfamily regulate various cell organelles during division.Being the key regulators of membrane dynamics, the dysregulation of small GTPases is widely associatedRecent discoveries shed light on the molecular properties of small GTPases as sophisticated modulatorsThis review collects current knowledge on small GTPases in the regulation of cell organelles during mitosisand highlights the mediator role of small GTPase in transducing cell cycle signaling to organelle dynamics

Keywords： small GTPase     cell organelle     mitosis    

HTML PDF Collect

Gut microbiota and its implications in small bowel transplantation

Chenyang Wang, Qiurong Li, Jieshou Li

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 239-248 doi: 10.1007/s11684-018-0617-0

Abstract: In fact, several studies indicated that acute and chronic allograft rejection in small bowel transplantation

Keywords： gut microbiota     small bowel transplantation     acute rejection     chronic rejection     mucosal immunity     biomarker    

HTML PDF Collect

Molecular classification of non-small-cell lung cancer: diagnosis, individualized treatment, and prognosis

Yue Yu, Jie He

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 157-171 doi: 10.1007/s11684-013-0272-4

Abstract:

Non-small-cell lung cancer (NSCLC) is the most common cause of premature death among the malignant

Keywords： non-small-cell lung cancer     molecular typing     individualized medicine     molecular-targeted therapy     gene expression    

HTML PDF Collect

Performance prediction of switched reluctance generator with time average and small signal models

Jyoti KOUJALAGI, B. UMAMAHESWARI, R. ARUMUGAM

Frontiers in Energy 2013, Volume 7, Issue 1,   Pages 56-68 doi: 10.1007/s11708-012-0216-8

Abstract: mathematical model and predicts the performance of switched reluctance generator with time average and smallFinally, to track control voltage and current wave shapes, a small signal model is designed.

Keywords： generator     reluctance     switching model     small signal model     time average model    

HTML PDF Collect

Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 18-42 doi: 10.1007/s11684-022-0976-4

Abstract: With the improved understanding of driver mutations in non-small cell lung cancer (NSCLC), expanding

Keywords： non-small cell lung cancer     driver mutations     treatment strategy     resistant mechanism     immune-checkpoint    

HTML PDF Collect

Paternal environmental exposure-induced spermatozoal small noncoding RNA alteration meditates the intergenerational

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 176-184 doi: 10.1007/s11684-021-0885-y

Abstract: Recently, small noncoding RNAs (sncRNAs) in sperm have seemed crucial to this transmission due to their

Keywords： small noncoding RNAs     epigenetic inheritance     paternal intergenerational inherence     extracellular vesicles    

HTML PDF Collect

Bevacizumab in combination with pemetrexed and platinum for elderly patients with advanced non-squamous non-small-cell

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 610-617 doi: 10.1007/s11684-021-0827-8

Abstract: Bevacizumab, an anti-VEGF monoclonal antibody, has significantly improved the clinical outcomes of patients with advanced non-squamous NSCLC (ns-NSCLC). However, the safety and efficacy of bevacizumab for elderly patients with advanced NSCLC require further investigation. Thus, 59 patients were included in the present retrospective study, 22 patients in the bevacizumab plus pemetrexed and platinum (B+PP) group, and 37 patients in the pemetrexed and platinum (PP) group. For the entire cohort of patients, the median OS was 33.3 months, and the 1-year and 2-year overall survival rates were 88.5% and 67.8%, respectively. The median OS and 1-year and 2-year OS rates were 20.5 months, 70.3% and 0%, respectively, in the B+PP group and 33.4 months, 97.0% and 89.4%, respectively, in the PP group (P <0.001). The incidence of grade≥3 adverse events was higher in the B+PP group than in the PP group (27.3% vs. 10.8%, respectively; P=0.204). Univariate and multivariate analyses suggested that the receipt of≥5 cycles of first-line chemotherapy was an independent favorable prognostic factor for OS, whereas the addition of bevacizumab was an unfavorable prognostic factor. With increased toxicities, the addition of bevacizumab to PP does not improve the overall survival of elderly patients with advanced ns-NSCLC.

Keywords： bevacizumab     elderly patient     advanced non-small-cell lung cancer     overall survival     toxicity    

HTML PDF Collect

Title Author Date Type Operation

Recent advances in small molecule fluorescent probes for simultaneous imaging of two bioactive molecules

Yongqing Zhou, Xin Wang, Wei Zhang, Bo Tang, Ping Li

Journal Article

Chemical transdifferentiation: closer to regenerative medicine

Aining Xu,Lin Cheng

Journal Article

Emerging immunological strategies: recent advances and future directions

Journal Article

NADPH oxidase and reactive oxygen species as signaling molecules in carcinogenesis

Gang WANG

Journal Article

Polymorphism of pharmaceutical molecules: perspectives on nucleation

Jie LU, Zhen LI, Xiaolin JIANG,

Journal Article

A ruptured recurrent small bowel gastrointestinal stromal tumour causing hemoperitoneum

Eric C.H. Lai,Kam Man Chung,Stephanie H.Y. Lau,Wan Yee Lau

Journal Article

Simulation and experimental improvement on a small-scale Stirling thermo-acoustic engine

Mao CHEN,Yonglin JU

Journal Article

Discovery of small molecule degraders for modulating cell cycle

Journal Article

Fine-tuning cell organelle dynamics during mitosis by small GTPases

Journal Article

Gut microbiota and its implications in small bowel transplantation

Chenyang Wang, Qiurong Li, Jieshou Li

Journal Article

Molecular classification of non-small-cell lung cancer: diagnosis, individualized treatment, and prognosis

Yue Yu, Jie He

Journal Article

Performance prediction of switched reluctance generator with time average and small signal models

Jyoti KOUJALAGI, B. UMAMAHESWARI, R. ARUMUGAM

Journal Article

Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future

Journal Article

Paternal environmental exposure-induced spermatozoal small noncoding RNA alteration meditates the intergenerational

Journal Article

Bevacizumab in combination with pemetrexed and platinum for elderly patients with advanced non-squamous non-small-cell

Journal Article